CD3E Antibody

Product Specifications

Background

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

NCBI Gene ID

916

Swiss Prot

P07766

Accession Number

P07766

Host

Rabbit

Reactivity

Human

Immunogen

This CD3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-182 amino acids from the C-terminal region of human CD3E.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

23 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CD3E

NCBI Official Name

T-cell surface glycoprotein CD3 epsilon chain

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Background Reference 03

Brophy, K., et al. BMC Med. Genet. 11, 76 (2010) :

Background Reference 04

Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

Other Product Names

T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E

Tested Applications

Protein ID

1345708

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FY-EH2373 96 Well

Human Sncα (Synuclein Alpha) ELISA Kit

Ask

View Details

RC202630A1V 250 µL

Human CARS (NM_001751) AAV Particle

Ask

View Details

243070-AP 100 µL

ACTN4 (Actinin, alpha 4, ActinIN-4, DKFZp686K23158, FSGS, FSGS1) (AP) discontinued

Ask

View Details

MBS6063786-01 100 mg

Di-tert-butyl-2-bromoethyliminodiacetate

Ask

View Details

MBS6063786-02 5x 100 mg

Di-tert-butyl-2-bromoethyliminodiacetate

Ask

View Details

GPC9939-K 25 L

Sodium Hypochlorite 14%

Ask

View Details