CCDC99 Antibody
Product Specifications
Background
CCDC99 is required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
NCBI Gene ID
54908
Swiss Prot
Q96EA4
Accession Number
Q96EA4
Host
Rabbit
Reactivity
Human
Immunogen
This CCDC99 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 459-488 amino acids from the C-terminal region of human CCDC99.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=57-083
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Symbol
SPDL1
NCBI Official Name
Protein Spindly {ECO:0000255|HAMAP-Rule:MF_03041}
NCBI Organism
Homo sapiens
Background Reference 01
Barisic, M., et al. Mol. Biol. Cell 21 (12) :1968-1981 (2010)
Background Reference 02
Gassmann, R., et al. Genes Dev. 24 (9) :957-971 (2010)
Background Reference 03
Chan, Y.W., et al. J. Cell Biol. 185 (5) :859-874 (2009)
Other Product Names
Protein Spindly {ECO:0000255|HAMAP-Rule:MF_03041}, hSpindly, Arsenite-related gene 1 protein, Coiled-coil domain-containing protein 99 {ECO:0000255|HAMAP-Rule:MF_03041}, Rhabdomyosarcoma antigen MU-RMS-404A, Spindle apparatus coiled-coil domain-containing protein 1 {ECO:0000255|HAMAP-Rule:MF_03041}, SPDL1 {ECO:0000255|HAMAP-Rule:MF_03041}
Tested Applications
WB, IHC-P
Protein ID
296452913
Physical Properties
Liquid
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