TBCC Antibody
Product Specifications
Background
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
NCBI Gene ID
6903
Swiss Prot
Q15814
Accession Number
Q15814
Host
Rabbit
Reactivity
Mouse
Immunogen
This TBCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human TBCC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TBCC
NCBI Official Name
Tubulin-specific chaperone C
NCBI Organism
Homo sapiens
Background Reference 01
Hage-Sleiman, R., et al. BMC Cancer 10, 135 (2010) :
Background Reference 02
Nature 447 (7145) :661-678 (2007)
Background Reference 03
Mungall, A.J., et al. Nature 425 (6960) :805-811 (2003)
Background Reference 04
Bartolini, F., et al. J. Biol. Chem. 277 (17) :14629-14634 (2002)
Other Product Names
Tubulin-specific chaperone C, Tubulin-folding cofactor C, CFC, TBCC
Tested Applications
WB
Protein ID
313104020
Physical Properties
Liquid
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