OGDH Antibody

Product Specifications

Background

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO (2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

NCBI Gene ID

4967

Swiss Prot

Q02218

Accession Number

Q02218

Host

Rabbit

Reactivity

Human

Immunogen

This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 amino acids from the C-terminal region of human OGDH.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

116 kDa

Fragment

Rabbit Ig

Symbol

OGDH

NCBI Official Name

2-oxoglutarate dehydrogenase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Van Bever, Y., et al. Am. J. Med. Genet.143 (7) :763-767 (2007)

Background Reference 02

Shi, Q., et al. J. Biol. Chem. 280 (12) :10888-10896 (2005)

Background Reference 03

Habelhah, H., et al. J. Biol. Chem. 279 (51) :53782-53788 (2004)

Background Reference 04

McCartney, R.G., et al. J. Biol. Chem. 273 (37) :24158-24164 (1998)

Other Product Names

2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, Alpha-ketoglutarate dehydrogenase, OGDH

Tested Applications

WB, IHC-P

Protein ID

160332299

Physical Properties

Liquid

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