HJURP Antibody

Product Specifications

Background

HJURP is a centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions.

NCBI Gene ID

55355

Swiss Prot

Q8NCD3

Accession Number

Q8NCD3

Host

Rabbit

Reactivity

Human

Immunogen

This HJURP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 559-588 amino acids from the C-terminal region of human HJURP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

84 kDa

Fragment

Rabbit Ig

Symbol

HJURP

NCBI Official Name

Holliday junction recognition protein

NCBI Organism

Homo sapiens

Background Reference 01

Sebastiani, P., et al. Science (2010) In press :

Background Reference 02

Shuaib, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (4) :1349-1354 (2010)

Background Reference 03

Hu, Z., et al. Breast Cancer Res. 12 (2), R18 (2010) :

Background Reference 04

Dunleavy, E.M., et al. Cell 137 (3) :485-497 (2009)

Other Product Names

Holliday junction recognition protein, 14-3-3-associated AKT substrate, Fetal liver-expressing gene 1 protein, Up-regulated in lung cancer 9, HJURP

Tested Applications

WB, IHC-P, Flow

Protein ID

239938642

Physical Properties

Liquid

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