PRRG1 Antibody

Product Specifications

Background

This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla) -containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

NCBI Gene ID

5638

Swiss Prot

O14668

Accession Number

O14668

Host

Rabbit

Reactivity

Human

Immunogen

This PRRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human PRRG1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

25 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PRRG1

NCBI Official Name

Transmembrane gamma-carboxyglutamic acid protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Background Reference 02

Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345 (3) :1022-1032 (2006)

Background Reference 03

Ross, M.T., et al. Nature 434 (7031) :325-337 (2005)

Background Reference 04

Kulman, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 94 (17) :9058-9062 (1997)

Other Product Names

Transmembrane gamma-carboxyglutamic acid protein 1, Proline-rich gamma-carboxyglutamic acid protein 1, Proline-rich Gla protein 1, PRRG1, PRGP1, TMG1

Tested Applications

Physical Properties

Liquid

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