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HDAC3 Antibody

Product Specifications

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq].

NCBI Gene ID

8841

Swiss Prot

O15379

Accession Number

O15379

Host

Rabbit

Reactivity

Human

Immunogen

This HDAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the C-terminal region of human HDAC3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-975

Calculated Molecular Weight

49 kDa

Fragment

Rabbit Ig

Symbol

HDAC3

NCBI Official Name

Histone deacetylase 3

NCBI Organism

Homo sapiens

Background Reference 01

Minamiya, Y., et al. Tumour Biol. 31 (5) :533-539 (2010)

Background Reference 02

Kim, H.C., et al. Cell. Mol. Life Sci. 67 (20) :3499-3510 (2010)

Background Reference 03

Yang, Z., et al. Clin. Chem. Lab. Med. (2010) In press :

Background Reference 04

Kim, T., et al. Psychiatry Res 178 (2) :266-269 (2010)

Other Product Names

Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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