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TRIM37 Antibody

Product Specifications

Background

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq].

NCBI Gene ID

4591

Swiss Prot

O94972

Accession Number

O94972

Host

Rabbit

Reactivity

Human

Immunogen

This TRIM37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 936-964 amino acids from the C-terminal region of human TRIM37.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

108 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRIM37

NCBI Official Name

E3 ubiquitin-protein ligase TRIM37

NCBI Organism

Homo sapiens

Background Reference 01

Xin, X., et al. Genome Res. 19 (7) :1262-1269 (2009)

Background Reference 02

Karlberg, S., et al. Mod. Pathol. 22 (4) :570-578 (2009)

Background Reference 03

Doganc, T., et al. Clin. Dysmorphol. 16 (3) :173-176 (2007)

Background Reference 04

Hamalainen, R.H., et al. Clin. Genet. 70 (6) :473-479 (2006)

Other Product Names

E3 ubiquitin-protein ligase TRIM37, 632-, Mulibrey nanism protein, Tripartite motif-containing protein 37, TRIM37, KIAA0898, MUL, POB1

Tested Applications

WB

Physical Properties

Liquid

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