TFAP2B Antibody

Product Specifications

Background

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq].

NCBI Gene ID

7021

Swiss Prot

Q92481

Accession Number

Q92481

Host

Rabbit

Reactivity

Human

Immunogen

This TFAP2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-462 amino acids from the C-terminal region of human TFAP2B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TFAP2B

NCBI Official Name

Transcription factor AP-2-beta

NCBI Organism

Homo sapiens

Background Reference 01

Li, X., et al. Genes Chromosomes Cancer 49 (9) :819-830 (2010)

Background Reference 02

Hotta, K., et al. J. Hum. Genet. (2010) In press :

Background Reference 03

Ugi, S., et al. Obesity (Silver Spring) 18 (7) :1277-1282 (2010)

Background Reference 04

Nordquist, N., et al. Brain Res. 1305 SUPPL, S20-S26 (2009) :

Other Product Names

Transcription factor AP-2-beta, AP2-beta, Activating enhancer-binding protein 2-beta, TFAP2B

Tested Applications

Protein ID

152031557

Physical Properties

Liquid

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