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PDE6A Antibody

Product Specifications

Background

This gene encodes the cyclic-GMP (cGMP) -specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

NCBI Gene ID

5145

Swiss Prot

P16499

Accession Number

P16499

Host

Rabbit

Reactivity

Human

Immunogen

This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

100 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDE6A

NCBI Official Name

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

NCBI Organism

Homo sapiens

Background Reference 01

Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Perlis, R.H., et al. Biol. Psychiatry 67 (11) :1110-1113 (2010)

Background Reference 04

Bazhin, A.V., et al. Cell. Mol. Life Sci. 67 (5) :817-828 (2010)

Other Product Names

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA

Tested Applications

WB

Protein ID

215274230

Physical Properties

Liquid

Frequently Asked Questions

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