BNIP3 Antibody

Product Specifications

Background

NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

NCBI Gene ID

664

Swiss Prot

Q12983

Accession Number

Q12983

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This BNIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-187 amino acids from human BNIP3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Autophagy

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Symbol

BNIP3

NCBI Official Name

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

NCBI Organism

Homo sapiens

Background Reference 01

References for protein:

Background Reference 02

Kothari, S., et al., Oncogene 22 (30) :4734-4744 (2003) .

Background Reference 03

Lee, S.M., et al., Life Sci. 71 (19) :2267-2277 (2002) .

Background Reference 04

Ray, R., et al., J. Biol. Chem. 275 (2) :1439-1448 (2000) .

Other Product Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BNIP3, NIP3

Tested Applications

WB, IHC-P, IF

Protein ID

20532402

Physical Properties

Liquid

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