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FGD2 Antibody

Product Specifications

Background

FGD2 activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity) .

NCBI Gene ID

221472

Swiss Prot

Q7Z6J4

Accession Number

Q7Z6J4

Host

Rabbit

Reactivity

Mouse

Immunogen

This FGD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 amino acids from the C-terminal region of human FGD2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

75 kDa

Fragment

Rabbit Ig

Symbol

FGD2

NCBI Official Name

FYVE, RhoGEF and PH domain-containing protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Huber, C., et al. J. Biol. Chem. 283 (49) :34002-34012 (2008)

Background Reference 02

Delague, V., et al. Am. J. Hum. Genet. 81 (1) :1-16 (2007)

Background Reference 03

Mungall, A.J., et al. Nature 425 (6960) :805-811 (2003)

Background Reference 04

Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :

Other Product Names

FYVE, RhoGEF and PH domain-containing protein 2, Zinc finger FYVE domain-containing protein 4, FGD2, ZFYVE4

Tested Applications

WB, IHC-P

Protein ID

61213572

Physical Properties

Liquid

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