ITM2B Antibody

Product Specifications

Background

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

NCBI Gene ID

9445

Swiss Prot

Q9Y287

Accession Number

Q9Y287

Host

Rabbit

Reactivity

Mouse

Immunogen

This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

30 kDa

Fragment

Rabbit Ig

Symbol

ITM2B

NCBI Official Name

Integral membrane protein 2B

NCBI Organism

Homo sapiens

Background Reference 01

Peng, S., et al. Biochem. Biophys. Res. Commun. 393 (3) :356-361 (2010)

Background Reference 02

Matsuda, S., et al. J. Biol. Chem. 284 (23) :15815-15825 (2009)

Background Reference 03

Matsuda, S., et al. Mol Neurodegener 4, 41 (2009) :

Background Reference 04

Tsachaki, M., et al. Biotechnol3 (12) :1548-1554 (2008)

Other Product Names

Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2