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CD320 Antibody

Product Specifications

Background

The CD320 antigen gene encodes the transcobalamin receptor (TCBLR) . Cellular uptake of cobalamin (vitamin B12) is mediated by receptors expressed on the cell surface. Transcobalamin II (TCN2; MIM 613441), a plasma protein secreted by endothelial cells, binds the cobalamin absorbed in the distal ileum and carries 10 to 30% of total circulating cobalamin. CD320 encodes a transcobalamin receptor that binds TCN2-cobalamin at the plasma membrane and internalizes the complex by endocytosis (Quadros et al., 2009 [PubMed 18779389]) .

NCBI Gene ID

51293

Swiss Prot

Q9NPF0

Accession Number

Q9NPF0

Host

Rabbit

Reactivity

Human

Immunogen

This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Cell Cycle, Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-874

Calculated Molecular Weight

29 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CD320

NCBI Official Name

CD320 antigen

NCBI Organism

Homo sapiens

Background Reference 01

Jiang, W., et al. Gene 466 (1-2), 49-55 (2010) :

Background Reference 02

Pangilinan, F., et al. J. Med. Genet. 47 (10) :677-685 (2010)

Background Reference 03

Quadros, E.V., et al. Hum. Mutat. 31 (8) :924-929 (2010)

Background Reference 04

Quadros, E.V., et al. Blood 113 (1) :186-192 (2009)

Other Product Names

CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A

Tested Applications

WB

Protein ID

74734303

Physical Properties

Liquid

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