PYDC1 Antibody

Product Specifications

Background

PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

NCBI Gene ID

260434

Swiss Prot

Q8WXC3

Accession Number

Q8WXC3

Host

Rabbit

Reactivity

Human

Immunogen

This PYDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the Central region of human PYDC1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

10 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PYDC1

NCBI Official Name

Pyrin domain-containing protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Son, Y.L., et al. Biochem. J. 410 (2) :319-330 (2008)

Background Reference 02

Natarajan, A., et al. J. Biol. Chem. 281 (42) :31863-31875 (2006)

Background Reference 03

Espejo, F., et al. Biochem. Biophys. Res. Commun. 340 (3) :860-864 (2006)

Background Reference 04

Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003) :

Other Product Names

Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, PYDC1, ASC2, ASCI, POP1, PYC1

Tested Applications

Protein ID

74730989

Physical Properties

Liquid

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