UNC13B Antibody
Product Specifications
Background
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq].
NCBI Gene ID
10497
Swiss Prot
O14795
Accession Number
O14795
Host
Rabbit
Reactivity
Mouse
Immunogen
This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the N-terminal region of human UNC13B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
181 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
UNC13B
NCBI Official Name
Protein unc-13 homolog B
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Goldenberg, N.M., et al. Am. J. Physiol., Cell Physiol. 297 (4), C1053-C1058 (2009) :
Background Reference 03
Dimova, K., et al. Biochemistry 48 (25) :5908-5921 (2009)
Background Reference 04
Tregouet, D.A., et al. Diabetes 57 (10) :2843-2850 (2008)
Other Product Names
Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13
Tested Applications
WB
Physical Properties
Liquid
Frequently Asked Questions
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