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ORC5L Antibody

Product Specifications

Background

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].

NCBI Gene ID

5001

Swiss Prot

O43913

Accession Number

O43913

Host

Rabbit

Reactivity

Mouse

Immunogen

This ORC5L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 amino acids from the Central region of human ORC5L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ORC5

NCBI Official Name

Origin recognition complex subunit 5

NCBI Organism

Homo sapiens

Background Reference 01

Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

Background Reference 02

Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

Background Reference 03

Siddiqui, K., et al. J. Biol. Chem. 282 (44) :32370-32383 (2007)

Background Reference 04

Clarke, C.A., et al. Biochem. J. 388 (PT 2), 705-712 (2005) :

Other Product Names

Origin recognition complex subunit 5, ORC5, ORC5L

Tested Applications

WB

Physical Properties

Liquid

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