LZTS1 Antibody

Product Specifications

Background

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.

NCBI Gene ID

11178

Swiss Prot

Q9Y250

Accession Number

Q9Y250

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This LZTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human LZTS1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

67 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

LZTS1

NCBI Official Name

Leucine zipper putative tumor suppressor 1

NCBI Organism

Homo sapiens

Background Reference 01

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 02

Chattopadhyay, I., et al. Mutat. Res. 696 (2) :130-138 (2010)

Background Reference 03

Califano, D., et al. J. Cell. Physiol. 222 (2) :382-386 (2010)

Background Reference 04

Shyn, S.I., et al. Mol. Psychiatry (2009) In press :

Other Product Names

Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1, FEZ1

Tested Applications

Protein ID

46396556

Physical Properties

Liquid

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