NAE1 Antibody

Product Specifications

Background

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

8883

Swiss Prot

Q13564

Accession Number

Q13564

Host

Rabbit

Reactivity

Human

Immunogen

This NAE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human NAE1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

NAE1

NCBI Official Name

NEDD8-activating enzyme E1 regulatory subunit

NCBI Organism

Homo sapiens

Background Reference 01

Jung, A.C., et al. Int. J. Cancer 126 (8) :1882-1894 (2010)

Background Reference 02

Park, Y., et al. Biochem. Biophys. Res. Commun. 374 (2) :294-298 (2008)

Background Reference 03

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

Background Reference 04

Li, T., et al. Arch. Biochem. Biophys. 453 (1) :70-74 (2006)

Other Product Names

NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1