CTPS2 Antibody

Product Specifications

Background

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

NCBI Gene ID

56474

Swiss Prot

Q9NRF8

Accession Number

Q9NRF8

Host

Rabbit

Reactivity

Human

Immunogen

This CTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human CTPS2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

66 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CTPS2

NCBI Official Name

CTP synthase 2

NCBI Organism

Homo sapiens

Background Reference 01

Kassel, K.M., et al. J. Biol. Chem. 285 (44) :33727-33736 (2010)

Background Reference 02

Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

Background Reference 03

Han, G.S., et al. J. Biol. Chem. 280 (46) :38328-38336 (2005)

Background Reference 04

Ross, M.T., et al. Nature 434 (7031) :325-337 (2005)

Other Product Names

CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2

Tested Applications

Protein ID

74752919

Physical Properties

Liquid

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