HERV-FRD Antibody

Product Specifications

Background

Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]) .

NCBI Gene ID

405754

Swiss Prot

P60508

Accession Number

P60508

Host

Rabbit

Reactivity

Human

Immunogen

This HERV-FRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the N-terminal region of human HERV-FRD.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ERVFRD-1

NCBI Official Name

Syncytin-2

NCBI Organism

Homo sapiens

Background Reference 01

Vargas, A., et al. J. Mol. Biol. 392 (2) :301-318 (2009)

Background Reference 02

Chen, C.P., et al. Biol. Reprod. 79 (5) :815-823 (2008)

Background Reference 03

Malassine, A., et al. Retrovirology 5, (2008) :

Background Reference 04

Mangeney, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104 (51) :20534-20539 (2007)

Other Product Names

Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, HERV-FRD_6p241 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERVFRD-1, ERVFRDE1