LARP7 Antibody

Product Specifications

Background

LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

NCBI Gene ID

51574

Swiss Prot

Q4G0J3

Accession Number

Q4G0J3

Host

Rabbit

Reactivity

Human

Immunogen

This LARP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the C-terminal region of human LARP7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

67 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

LARP7

NCBI Official Name

La-related protein 7

NCBI Organism

Homo sapiens

Background Reference 01

Tyagi, M., et al. J. Virol. 84 (13) :6425-6437 (2010)

Background Reference 02

Kalsi, G., et al. Hum. Mol. Genet. 19 (12) :2497-2506 (2010)

Background Reference 03

Markert, A., et al. EMBO Rep. 9 (6) :569-575 (2008)

Background Reference 04

Krueger, B.J., et al. Nucleic Acids Res. 36 (7) :2219-2229 (2008)

Other Product Names

La-related protein 7, La ribonucleoprotein domain family member 7, P-TEFb-interaction protein for 7SK stability, PIP7S, LARP7

Tested Applications

Protein ID

121945944

Physical Properties

Liquid

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