MBTPS2 Antibody

Product Specifications

Background

This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome) ; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

NCBI Gene ID

51360

Swiss Prot

O43462

Accession Number

O43462

Host

Rabbit

Reactivity

Human

Immunogen

This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Symbol

MBTPS2

NCBI Official Name

Membrane-bound transcription factor site-2 protease

NCBI Organism

Homo sapiens

Background Reference 01

Ming, A., et al. Pediatr Dermatol 26 (4) :427-431 (2009)

Background Reference 02

Oeffner, F., et al. Am. J. Hum. Genet. 84 (4) :459-467 (2009)

Background Reference 03

Lu, Y., et al. J. Lipid Res. 49 (12) :2582-2589 (2008)

Background Reference 04

Shen, J., et al. J. Biol. Chem. 279 (41) :43046-43051 (2004)

Other Product Names

Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P