PAICS Antibody

Product Specifications

Background

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

10606

Swiss Prot

P22234

Accession Number

P22234

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PAICS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human PAICS.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Symbol

PAICS

NCBI Official Name

Multifunctional protein ADE2

NCBI Organism

Homo sapiens

Background Reference 01

Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)

Background Reference 02

Ikeda, M., et al. Biol. Psychiatry 67 (3) :263-269 (2010)

Background Reference 03

Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

Background Reference 04

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Other Product Names

Multifunctional protein ADE2, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase, Phosphoribosylaminoimidazole carboxylase, AIR carboxylase, AIRC, PAICS, ADE2, AIRC, PAIS