CPN1 Antibody
Product Specifications
Background
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq].
NCBI Gene ID
1369
Swiss Prot
P15169
Accession Number
P15169
Host
Rabbit
Reactivity
Human
Immunogen
This CPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the Central region of human CPN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=56-714
Calculated Molecular Weight
52 kDa
Fragment
Rabbit Ig
Symbol
CPN1
NCBI Official Name
Carboxypeptidase N catalytic chain
NCBI Organism
Homo sapiens
Background Reference 01
Speliotes, E.K., et al. Hepatology 52 (3) :904-912 (2010)
Background Reference 02
Ichikawa, S., et al. J. Bone Miner. Res. 25 (8) :1821-1829 (2010)
Background Reference 03
Du, X.Y., et al. J. Biol. Chem. 284 (2) :751-758 (2009)
Background Reference 04
Yuan, X., et al. Am. J. Hum. Genet. 83 (4) :520-528 (2008)
Other Product Names
Carboxypeptidase N catalytic chain, CPN, Anaphylatoxin inactivator, Arginine carboxypeptidase, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, Serum carboxypeptidase N, SCPN, CPN1, ACBP
Tested Applications
WB, IHC-P, Flow
Protein ID
115896
Physical Properties
Liquid
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