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PVRL3 Antibody

Product Specifications

Background

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559) . Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090) -catenin (see MIM 116805) system in epithelial cells.

NCBI Gene ID

25945

Swiss Prot

Q9NQS3

Accession Number

Q9NQS3

Host

Rabbit

Reactivity

Human

Immunogen

This PVRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-536 amino acids from the C-terminal region of human PVRL3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PVRL3

NCBI Official Name

Nectin-3

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 03

Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

Background Reference 04

Yu, X., et al. Nat. Immunol. 10 (1) :48-57 (2009)

Other Product Names

Nectin-3, CDw113, Poliovirus receptor-related protein 3, CD113, PVRL3, PRR3

Tested Applications

WB

Protein ID

74762752

Physical Properties

Liquid

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