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PIK3AP1 Antibody

Product Specifications

Background

PIK3AP1 is involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity) . May be involved in the survival of mature B cells via activation of REL (By similarity) .

NCBI Gene ID

118788

Swiss Prot

Q6ZUJ8

Accession Number

Q6ZUJ8

Host

Rabbit

Reactivity

Human

Immunogen

This PIK3AP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-668 amino acids from the C-terminal region of human PIK3AP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

90 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PIK3AP1

NCBI Official Name

Phosphoinositide 3-kinase adapter protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Koutros, S., et al. Cancer Res. 70 (6) :2389-2396 (2010)

Background Reference 02

Rikova, K., et al. Cell 131 (6) :1190-1203 (2007)

Background Reference 03

Grupe, A., et al. Am. J. Hum. Genet. 78 (1) :78-88 (2006)

Background Reference 04

Maruoka, M., et al. FEBS Lett. 579 (14) :2986-2990 (2005)

Other Product Names

Phosphoinositide 3-kinase adapter protein 1, B-cell adapter for phosphoinositide 3-kinase, B-cell phosphoinositide 3-kinase adapter protein 1, PIK3AP1, BCAP

Tested Applications

WB

Protein ID

205830907

Physical Properties

Liquid

Frequently Asked Questions

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