PUS1 Antibody

Product Specifications

Background

This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.

NCBI Gene ID

80324

Swiss Prot

Q9Y606

Accession Number

Q9Y606

Host

Rabbit

Reactivity

Human

Immunogen

This PUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the C-terminal region of human PUS1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Symbol

PUS1

NCBI Official Name

TRNA pseudouridine synthase A, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Bergmann, A.K., et al. Pediatr Blood Cancer 54 (2) :273-278 (2010)

Background Reference 02

Sibert, B.S., et al. RNA 14 (9) :1895-1906 (2008)

Background Reference 03

Rikova, K., et al. Cell 131 (6) :1190-1203 (2007)

Background Reference 04

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Other Product Names

TRNA pseudouridine synthase A, mitochondrial, tRNA pseudouridine (38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I, PUS1

Tested Applications

WB, IHC-P

Protein ID

114152895

Physical Properties

Liquid

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