ABRA Antibody

Product Specifications

Background

ABRA acts as an activator of serum response factor (SRF) -dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) .

NCBI Gene ID

137735

Swiss Prot

Q8N0Z2

Accession Number

Q8N0Z2

Host

Rabbit

Reactivity

Human

Immunogen

This ABRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-304 amino acids from the C-terminal region of human ABRA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Symbol

ABRA

NCBI Official Name

Actin-binding Rho-activating protein

NCBI Organism

Homo sapiens

Background Reference 01

Lamon, S., et al. J. Physiol. (Lond.) 587 (PT 8), 1795-1803 (2009) Kuwahara, K., et al. J. Clin. Invest. 117 (5) :1324-1334 (2007) Kuwahara, K., et al. Mol. Cell. Biol. 25 (8) :3173-3181 (2005) Arai, A., et al. J. Biol. Chem. 277 (27) :24453-24459 (2002) Simpson, J.C., et al. EMBO Rep. 1 (3) :287-292 (2000)