LIN7C Antibody

Product Specifications

Background

LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

NCBI Gene ID

55327

Swiss Prot

Q9NUP9

Accession Number

Q9NUP9

Host

Rabbit

Reactivity

Human

Immunogen

This LIN7C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human LIN7C.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Symbol

LIN7C

NCBI Official Name

Protein lin-7 homolog C

NCBI Organism

Homo sapiens

Background Reference 01

Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95 (5) :2418-2425 (2010)

Background Reference 02

Lanktree, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 147B (6), 945-951 (2008) :

Background Reference 03

Bulgin, N.L., et al. Neuromolecular Med. 10 (4) :343-355 (2008)

Background Reference 04

Onda, T., et al. Cancer Res. 67 (20) :9643-9648 (2007)

Other Product Names

Protein lin-7 homolog C, Lin-7C, Mammalian lin-seven protein 3, MALS-3, Vertebrate lin-7 homolog 3, Veli-3, LIN7C, MALS3, VELI3

Tested Applications

WB, IHC-P

Protein ID

59798474

Physical Properties

Liquid

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