SULF2 Antibody

Product Specifications

Background

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]) .

NCBI Gene ID

55959

Swiss Prot

Q8IWU5

Accession Number

Q8IWU5

Host

Rabbit

Reactivity

Human

Immunogen

This SULF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 824-852 amino acids from the C-terminal region of human SULF2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

100 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SULF2

NCBI Official Name

Extracellular sulfatase Sulf-2

NCBI Organism

Homo sapiens

Background Reference 01

Lai, J.P., et al. Hepatology 52 (5) :1680-1689 (2010) Ellinor, P.T., et al. Nat. Genet. 42 (3) :240-244 (2010) Lemjabbar-Alaoui, H., et al. Oncogene 29 (5) :635-646 (2010) Tang, R., et al. J. Biol. Chem. 284 (32) :21505-21514 (2009) Chau, B.N., et al. Cancer Res. 69 (4) :1368-1374 (2009)