FKTN Antibody
Product Specifications
Background
The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X) . Alternatively spliced transcript variants have been found for this gene.
NCBI Gene ID
2218
Swiss Prot
O75072
Accession Number
O75072
Host
Rabbit
Reactivity
Human
Immunogen
This FKTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human FKTN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
FKTN
NCBI Official Name
Fukutin
NCBI Organism
Homo sapiens
Background Reference 01
Lim, B.C., et al. Neuromuscul. Disord. 20 (8) :524-530 (2010)
Background Reference 02
Saredi, S., et al. Muscle Nerve 39 (6) :845-848 (2009)
Background Reference 03
Chang, W., et al. Prenat. Diagn. 29 (6) :560-569 (2009)
Background Reference 04
Mercuri, E., et al. Neurology 72 (21) :1802-1809 (2009)
Other Product Names
Fukutin, 2---, Fukuyama-type congenital muscular dystrophy protein, FKTN, FCMD
Tested Applications
WB, IHC-P
Physical Properties
Liquid
Curated Selection
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