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TPM4 Antibody

Product Specifications

Background

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

NCBI Gene ID

7171

Swiss Prot

P67936

Accession Number

P67936

Host

Rabbit

Reactivity

Human

Immunogen

This TPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human TPM4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

29 kDa

Fragment

Rabbit Ig

Symbol

TPM4

NCBI Official Name

Tropomyosin alpha-4 chain

NCBI Organism

Homo sapiens

Background Reference 01

Martins-de-Souza, D., et al.Psychiatr Res 44 (14) :989-991 (2010)

Background Reference 02

Vlahovich, N., et al. Cell Motil. Cytoskeleton 65 (1) :73-85 (2008)

Background Reference 03

Montesano Gesualdi, N., et al. Free Radic. Res. 40 (5) :467-476 (2006)

Background Reference 04

Hossain, M.M., et al. J. Biol. Chem. 280 (51) :42442-42453 (2005)

Other Product Names

Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4

Tested Applications

WB, Flow

Protein ID

54039751

Physical Properties

Liquid

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