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NPHP3 Antibody

Product Specifications

Background

This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin and may function in renal tubular development and function. Mutations in this gene are associated with nephronophthisis type 3. Multiple splice variants have been described but their full-length nature has not been determined.

NCBI Gene ID

27031

Swiss Prot

Q7Z494

Accession Number

Q7Z494

Host

Rabbit

Reactivity

Human

Immunogen

This NPHP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the N-terminal region of human NPHP3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Zebrafish, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

151 kDa

Fragment

Rabbit Ig

Symbol

NPHP3

NCBI Official Name

Nephrocystin-3

NCBI Organism

Homo sapiens

Background Reference 01

Simpson, M.A., et al. Am. J. Kidney Dis. 53 (5) :790-795 (2009)

Background Reference 02

Tory, K., et al. Kidney Int. 75 (8) :839-847 (2009)

Background Reference 03

Bergmann, C., et al. Am. J. Hum. Genet. 82 (4) :959-970 (2008)

Background Reference 04

Hoefele, J., et al. J. Am. Soc. Nephrol. 18 (10) :2789-2795 (2007)

Other Product Names

Nephrocystin-3, NPHP3, KIAA2000

Tested Applications

WB, IHC-P

Protein ID

68565783

Physical Properties

Liquid

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