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SGPL1 Antibody

Product Specifications

Background

SGPL1 cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

NCBI Gene ID

8879

Swiss Prot

O95470

Accession Number

O95470

Host

Rabbit

Reactivity

Human

Immunogen

This SGPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human SGPL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Symbol

SGPL1

NCBI Official Name

Sphingosine-1-phosphate lyase 1

NCBI Organism

Homo sapiens

Background Reference 01

Seo, Y.J., et al. J. Virol. 84 (16) :8124-8131 (2010)

Background Reference 02

Vogel, P., et al. PLoS ONE (1), E4112 (2009) :

Background Reference 03

Peest, U., et al. J. Cell. Biochem. 104 (3) :756-772 (2008)

Background Reference 04

Morgan, A.R., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 144B (6), 762-770 (2007) :

Other Product Names

Sphingosine-1-phosphate lyase 1, S1PL, SP-lyase 1, SPL 1, hSPL, Sphingosine-1-phosphate aldolase, SGPL1, KIAA1252

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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