CNGB3 Antibody
Product Specifications
Background
This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease.
NCBI Gene ID
54714
Swiss Prot
Q9NQW8
Accession Number
Q9NQW8
Host
Rabbit
Reactivity
Human
Immunogen
This CNGB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human CNGB3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
92 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CNGB3
NCBI Official Name
Cyclic nucleotide-gated cation channel beta-3
NCBI Organism
Homo sapiens
Background Reference 01
Komaromy, A.M., et al. Hum. Mol. Genet. 19 (13) :2581-2593 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Thiadens, A.A., et al. Ophthalmology 117 (4) :825-830 (2010)
Background Reference 04
Azam, M., et al. Mol. Vis. 16, 774-781 (2010) :
Other Product Names
Cyclic nucleotide-gated cation channel beta-3, Cone photoreceptor cGMP-gated channel subunit beta, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-3, CNG channel beta-3, CNGB3
Tested Applications
WB
Protein ID
311033366
Physical Properties
Liquid
Frequently Asked Questions
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