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PLOD1 Antibody

Product Specifications

Background

Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity.

NCBI Gene ID

5351

Swiss Prot

Q02809

Accession Number

Q02809

Host

Rabbit

Reactivity

Human

Immunogen

This PLOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human PLOD1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-571

Calculated Molecular Weight

84 kDa

Fragment

Rabbit Ig

Symbol

PLOD1

NCBI Official Name

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

NCBI Organism

Homo sapiens

Background Reference 01

Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :

Background Reference 02

Huang, Q.Y., et al. Bone 44 (5) :984-988 (2009)

Background Reference 03

Yamada, Y., et al. Int. J. Mol. Med. 19 (5) :791-801 (2007)

Background Reference 04

Tasker, P.N., et al. Osteoporos Int 17 (7) :1078-1085 (2006)

Other Product Names

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1, Lysyl hydroxylase 1, LH1, PLOD1, LLH, PLOD

Tested Applications

WB, IHC-P, Flow

Protein ID

78099790

Physical Properties

Liquid

Curated Selection

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