TMEM43 Antibody

Product Specifications

Background

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) . Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.

NCBI Gene ID

79188

Swiss Prot

Q9BTV4

Accession Number

Q9BTV4

Host

Rabbit

Reactivity

Human

Immunogen

This TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Symbol

TMEM43

NCBI Official Name

Transmembrane protein 43

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Barahona-Dussault, C., et al. Clin. Genet. 77 (1) :37-48 (2010)

Background Reference 03

Hodgkinson, K., et al. Genet. Med. 11 (12) :859-865 (2009)

Background Reference 04

Merner, N.D., et al. Am. J. Hum. Genet. 82 (4) :809-821 (2008)

Other Product Names

Transmembrane protein 43, Protein LUMA, TMEM43

Tested Applications

WB, IHC-P

Protein ID

74733151

Physical Properties

Liquid

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