APEH Antibody
Product Specifications
Background
APEH is the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. APEH gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. The protein can play an important role in destroying oxidatively damaged proteins in living cells.
NCBI Gene ID
327
Swiss Prot
P13798
Accession Number
P13798
Host
Rabbit
Reactivity
Human
Immunogen
This APEH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-204 amino acids from the N-terminal region of human APEH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=56-505
Calculated Molecular Weight
81 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
APEH
NCBI Official Name
Acylamino-acid-releasing enzyme
NCBI Organism
Homo sapiens
Background Reference 01
Perrier, J., Giardina, T. Biol. Cell 94 (1), 45-54 (2002)
Background Reference 02
Erlandsson, R., Boldog, F. Oncogene (7), 1293-1295 (1991)
Background Reference 03
Erlandsson, R., Bergerheim, U.S. Oncogene (8), 1207-1211 (1990)
Other Product Names
Acylamino-acid-releasing enzyme, AARE, Acyl-peptide hydrolase, APH, Acylaminoacyl-peptidase, Oxidized protein hydrolase, OPH, APEH, D3F15S2, D3S48E, DNF15S2
Tested Applications
WB
Protein ID
38258902
Physical Properties
Liquid
Curated Selection
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