CTNND2 Antibody

Product Specifications

Background

This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.

NCBI Gene ID

1501

Swiss Prot

Q9UQB3

Accession Number

Q9UQB3

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CTNND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1131-1159 amino acids from the C-terminal region of human CTNND2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

133 kDa

Fragment

Rabbit Ig

Symbol

CTNND2

NCBI Official Name

Catenin delta-2

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Zhang, J., et al. Exp. Cell Res. 316 (6) :1070-1081 (2010)

Background Reference 03

Yang, I., et al. Mol. Cells 29 (3) :233-237 (2010)

Background Reference 04

Stenzel, N., et al. J. Cell. Sci. 122 (PT 18), 3374-3384 (2009) :

Other Product Names

Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP

Tested Applications

WB, IHC-P

Protein ID

84028193

Physical Properties

Liquid

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