FAP Antibody

Product Specifications

Background

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

NCBI Gene ID

2191

Swiss Prot

Q12884

Accession Number

Q12884

Host

Rabbit

Reactivity

Human

Immunogen

This FAP antibody is generated from rabbits immunized with the protein of human FAP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by dialysis against PBS

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

88 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FAP

NCBI Official Name

Prolyl endopeptidase FAP

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) Ospelt, C., et al. Arthritis Rheum. 62 (5) :1224-1235 (2010) Stremenova, J., et al. Int. J. Oncol. 36 (2) :351-358 (2010) Chen, H., et al. Exp. Mol. Pathol. 87 (3) :189-194 (2009) Dohi, O., et al. Histopathology 55 (4) :432-440 (2009)