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PSTPIP1 Antibody

Product Specifications

Background

The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.

NCBI Gene ID

9051

Swiss Prot

O43586

Accession Number

O43586

Host

Rabbit

Reactivity

Human

Immunogen

This PSTPIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the N-terminal region of human PSTPIP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=56-465

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Symbol

PSTPIP1

NCBI Official Name

Proline-serine-threonine phosphatase-interacting protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Andre, M.F., et al. Dig. Dis. Sci. 55 (6) :1681-1688 (2010)

Background Reference 02

Rose, J. Phd, et al. Mol. Med. (2010) In press :

Background Reference 03

Hong, J.B., et al. J. Am. Acad. Dermatol. 61 (3) :533-535 (2009)

Background Reference 04

Voss, M., et al. BMC Immunol. 10, 53 (2009) :

Other Product Names

Proline-serine-threonine phosphatase-interacting protein 1, PEST phosphatase-interacting protein 1, CD2-binding protein 1, H-PIP, PSTPIP1, CD2BP1

Tested Applications

WB, Flow

Physical Properties

Liquid

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