SPG7 Antibody
Product Specifications
Background
This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7. [provided by RefSeq].
NCBI Gene ID
6687
Swiss Prot
Q9UQ90
Accession Number
Q9UQ90
Host
Rabbit
Reactivity
Human
Immunogen
This SPG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-141 amino acids from the Central region of human SPG7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
88 kDa
Fragment
Rabbit Ig
Symbol
SPG7
NCBI Official Name
Paraplegin
NCBI Organism
Homo sapiens
Background Reference 01
Warnecke, T., et al. Mov. Disord. 25 (4) :413-420 (2010)
Background Reference 02
Augustin, S., et al. Mol. Cell 35 (5) :574-585 (2009)
Background Reference 03
Karlberg, T., et al. PLoS ONE (10), E6975 (2009) :
Background Reference 04
Brugman, F., et al. Neurology 71 (19) :1500-1505 (2008)
Other Product Names
Paraplegin, 3424-, Spastic paraplegia 7 protein, SPG7, CAR, CMAR, PGN
Tested Applications
WB, IHC-P
Protein ID
116242796
Physical Properties
Liquid
Curated Selection
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