Sestrin-3 Antibody
Product Specifications
Background
Sestrins form a small family of redox enzymes which regulate accumulation of Reactive Oxygen Species. They protect cells and their DNA against oxidative damage and regulate cell growth and viability. These genes are often deregulated in cancers and their inactivation accelerates the growth of model tumors in mice.
NCBI Gene ID
143686
Swiss Prot
P58005
Accession Number
P58005
Host
Rabbit
Reactivity
Human
Immunogen
This Sestrin-3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-347 amino acids from the Central region of human Sestrin-3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Symbol
SESN3
NCBI Official Name
Sestrin-3
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Chen, C.C., et al. Dev. Cell 18 (4) :592-604 (2010)
Background Reference 03
Peeters, H., et al. Hum. Genet. 112 (5-6), 573-580 (2003) :
Other Product Names
Sestrin-3, SESN3, SEST3
Tested Applications
WB, IHC-P
Protein ID
20141774
Physical Properties
Liquid
Frequently Asked Questions
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