MYBPC3 Antibody

Product Specifications

Background

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

NCBI Gene ID

4607

Swiss Prot

Q14896

Accession Number

Q14896

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This MYBPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

141 kDa

Fragment

Rabbit IgG

Symbol

MYBPC3

NCBI Official Name

Myosin-binding protein C, cardiac-type

NCBI Organism

Homo sapiens

Background Reference 01

Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Millat, G., et al. EurMed Genet 53 (5) :261-267 (2010)

Background Reference 04

Zimmerman, R.S., et al. Genet. Med. 12 (5) :268-278 (2010)

Other Product Names

Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3

Tested Applications

WB, IHC-P

Protein ID

425906074

Physical Properties

Liquid

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