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TCF7L2 Antibody

Product Specifications

Background

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

NCBI Gene ID

6934

Swiss Prot

Q9NQB0

Accession Number

Q9NQB0

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This TCF7L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human TCF7L2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

TCF7L2

NCBI Official Name

Transcription factor 7-like 2

NCBI Organism

Homo sapiens

Background Reference 01

Hansson, O., et al. Curr. Diab. Rep. 10 (6) :444-451 (2010)

Background Reference 02

Heni, M., et al. Diabetes (2010) In press :

Background Reference 03

Potapov, V.A., et al. Genetika 46 (8) :1123-1131 (2010)

Background Reference 04

Kucharska-Newton, A.M., et al.Obes 2010 (2010) :

Other Product Names

Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, TCF-4, hTCF-4, TCF7L2, TCF4

Tested Applications

WB

Protein ID

29337146

Physical Properties

Liquid

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