ST6GALNAC1 Antibody
Product Specifications
Background
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]) .
NCBI Gene ID
55808
Swiss Prot
Q9NSC7
Accession Number
Q9NSC7
Host
Rabbit
Reactivity
Human
Immunogen
This ST6GALNAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-57 amino acids from the N-terminal region of human ST6GALNAC1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
69 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ST6GALNAC1
NCBI Official Name
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Hassinen, A., et al. J. Biol. Chem. 285 (23) :17771-17777 (2010)
Background Reference 03
Patani, N., et al. Cancer Genomics Proteomics 5 (6) :333-340 (2008)
Background Reference 04
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Other Product Names
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, GalNAc alpha-2,6-sialyltransferase I, ST6GalNAc I, ST6GalNAcI, Sialyltransferase 7A, SIAT7-A, ST6GALNAC1, SIAT7A
Tested Applications
WB
Protein ID
21759444
Physical Properties
Liquid
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