SLC12A7 Antibody

Product Specifications

Background

SLC12A7 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K (+) uptake into Deiters' cells in the cochlea and contribute to K (+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl (-) extrusion in the kidney and contribute to renal acidification (By similarity) .

NCBI Gene ID

10723

Swiss Prot

Q9Y666

Accession Number

Q9Y666

Host

Rabbit

Reactivity

Human

Immunogen

This SLC12A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human SLC12A7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

119 kDa

Fragment

Rabbit Ig

Symbol

SLC12A7

NCBI Official Name

Solute carrier family 12 member 7

NCBI Organism

Homo sapiens

Background Reference 01

Hartmann, A.M., et al. J. Biol. Chem. 285 (31) :23994-24002 (2010)

Background Reference 02

Kamatani, Y., et al. Nat. Genet. 42 (3) :210-215 (2010)

Background Reference 03

Chen, Y.F., et al. Cancer Res. 69 (22) :8585-8593 (2009)

Background Reference 04

Fujii, T., et al. J. Biol. Chem. 284 (1) :619-629 (2009)

Other Product Names

Solute carrier family 12 member 7, Electroneutral potassium-chloride cotransporter 4, K-Cl cotransporter 4, SLC12A7, KCC4

Tested Applications

WB, IHC-P

Protein ID

166202480

Physical Properties

Liquid

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