ZNF146 Antibody
Product Specifications
Background
The ZNF146 protein is a 33 kDa Kruppel protein, composed solely of 10 zinc finger motifs. ZNF146 overexpression in tumours may alter the balance between hRap1 and other telomeric proteins; therefore ZNF146 function may be linked to telomere regulation. ZNF146 is strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. ZNF146 is overexpresseed in 80% of colorectal cancers.
NCBI Gene ID
7705
Swiss Prot
Q15072
Accession Number
Q15072
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ZNF146 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human ZNF146.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Symbol
ZNF146
NCBI Official Name
Zinc finger protein OZF
NCBI Organism
Homo sapiens
Background Reference 01
Antoine, K., et al. J. Cell. Biochem. 95 (4) :763-768 (2005)
Background Reference 02
Antoine, K., et al. Mol. Cell. Biochem. 271 (1-2), 215-223 (2005) :
Background Reference 03
Grimwood, J., et al. Nature 428 (6982) :529-535 (2004)
Background Reference 04
Ferbus, D., et al. J. Pathol. 200 (2) :177-182 (2003)
Other Product Names
Zinc finger protein OZF, Only zinc finger protein, Zinc finger protein 146, ZNF146, OZF
Tested Applications
WB, Flow
Protein ID
134048495
Physical Properties
Liquid
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