MAD1L1 Antibody

Product Specifications

Background

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

NCBI Gene ID

8379

Swiss Prot

Q9Y6D9

Accession Number

Q9Y6D9

Host

Rabbit

Reactivity

Human

Immunogen

This MAD1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-151 amino acids from the N-terminal region of human MAD1L1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

83 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MAD1L1

NCBI Official Name

Mitotic spindle assembly checkpoint protein MAD1

NCBI Organism

Homo sapiens

Background Reference 01

Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

Background Reference 02

Guo, Y., et al. J. Med. Genet. 47 (9) :616-622 (2010)

Background Reference 03

Wang, H.B., et al. J. Gastrointest. Surg. 14 (8) :1227-1234 (2010)

Background Reference 04

Hewitt, L., et al. J. Cell Biol. 190 (1) :25-34 (2010)

Other Product Names

Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, hMAD1, Tax-binding protein 181, MAD1L1, MAD1, TXBP181